Born on 25 January 1985 to an Ukrainian mother and Jewish father in Orotukan, Magadan Oblast, Russian Far East, Karol moved to Ivano-Frankivsk, Ukraine at the age of six. Her father, Grigoriy Liberman was from Vashkivtsi, Ukraine. Karol confessed in 2006 she often felt discriminated against in school because of her Jewish last name. She is fluent in both Ukrainian and Russian. As a teenager Karol (under her real name Tetyana Liberman) performed for four years with the dancing ensemble at the Kyiv branch of the Jewish Agency, and her repertoire included songs in Hebrew and in Yiddish. In 2000 she with this ensemble traveled to the United States, where the group’s appearances raised money for Jewish Agency for Israel programs in Ukraine.
Karol graduated from a music school, and later from the Gliere Music College in Kiev, where she studied pop vocal in the Faculty of Singing. In her fourth year, she was awarded a scholarship by the Verkhovna Rada (Ukraine's parliament). Karol has participated in numerous youth, regional, international and Jewish singing contests as well as musicals and theatrical shows. Karol became the soloist of the Ensemble of Song and Dance of the Ukrainian Armed Forces as well as a television personality.
In 2005, Karol traveled to Iraq and Kosovo to perform for the peace keepers stationed there. She was the first performer to come to Iraq. She reached second place at the Latvian festival "New Wave". In 2005 she took a less Jewish stage name after producers of "New Wave" had suggested that to her. In 2006 she commented on this "It was a part of my agreement with the producers, but, to be honest, I am glad I changed my name. I felt like it hindered me in my lifeâ€.
In 2006 Karol won at the casting for the Eurovision Song Contest 2006 with the song "I Am Your Queen" and therefore represented Ukraine at the event finishing 7th, scoring 145 points, with a revised version of the song entitled "Show Me Your Love". In 2006, Tina Karol released her debut album Show Me Your Love, and another album entitled Nochenka, with some of songs of the first album in Russian and Ukrainian. Also in 2006 she started studying by correspondence at the National Aviation University in Kiev. In 2006, she also participated in the United Nations's Unite for Children, Unite Against AIDS campaign against HIV/AIDS in Ukraine.
In 2007, she released her new album Polyus Prityazheniya and wrote a fairy tale, Pautinka, a story about a caterpillar, portraying the show business as Tina has experienced it. Philipp Kirkorov, Alla Pugacheva and Verka Serduchka all have "parts" in the story.
On 16 January 2009, Viktor Yushchenko awarded Karol the title of Honored Artist of Ukraine. Since September 2009 Karol actively supported the candidature of Yulia Tymoshenko for the Ukrainian presidential election, 2010. In October 2009 she was ranked 92nd in a top 100 of "most influential women in Ukraine" compiled by experts for the Ukrainian magazine Focus.