"How to Save a Life" is a song by American pop rock band The Fray. It was released as the second single from their debut studio album of the same name on August 28, 2005. The song is one of the band's most popular airplay songs and peaked in the top 3 of the Billboard Hot 100 chart in the United States. It became the joint seventh longest charting single on the Billboard Hot 100, tying with Santana's "Smooth" (1999), at 58 consecutive weeks. The song has been certified 3x Platinum by the RIAA, and has sold 4.7 million downloads as of January 2015, the fourth best-selling rock song in digital history.

It is the band's highest-charting song to date, topping the Adult Top 40 chart for 15 consecutive weeks and topping the Canadian Airplay Chart. It was also nominated for a Grammy Award for Best Rock Performance by a Duo or Group with Vocal in 2007, but lost to "Dani California" by Red Hot Chili Peppers.